Who should not take RUKOBIA?

Do not take RUKOBIA if you:

  • are allergic to fostemsavir or any of the ingredients in RUKOBIA
  • take certain medicines, including enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, and St. John’s wort (Hypericum perforatum)

What are the possible side effects of RUKOBIA?

RUKOBIA can cause serious side effects, including:

  • Changes in your immune system. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having new symptoms after you start taking RUKOBIA
  • Heart rhythm problems (QTc prolongation). RUKOBIA may cause a heart rhythm problem called QTc prolongation. QTc prolongation causes an irregular heartbeat. If you are elderly, you may be at a greater risk for developing this heart problem with RUKOBIA. Tell your healthcare provider right away if you feel dizzy, lightheaded, feel changes in your heartbeat, or you faint (lose consciousness)
  • Changes in liver function blood tests results. People with HIV-1 who take RUKOBIA and who also have hepatitis B or C virus infections may be more likely to develop new or worsening changes in certain liver function blood tests during treatment with RUKOBIA
    • If you stop your anti-hepatitis B treatment, this could mean that your hepatitis B may become active again (reactivated). Your healthcare provider may do blood tests to check your liver function
    • Take any anti-hepatitis B or anti-hepatitis C medicines as prescribed by your healthcare provider during treatment with RUKOBIA

The most common side effect of RUKOBIA is nausea.

These are not all of the possible side effects of RUKOBIA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

FDA=Food and Drug Administration; HIV-1=human immunodeficiency virus type-1; MDR=multidrug-resistant.

Talk to your doctor

Here are some questions about RUKOBIA you can ask at your next appointment.

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